Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abi7400
Abstract: Description Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis. Amplifying rheumatoid arthritis Inflammation requires metabolic reprogramming of monocytes and macrophages to support immune responses, such as the synthesis of the proinflammatory… read more here.
Keywords: zinc; zip8; monocytes macrophages; rheumatoid arthritis ... See more keywords
Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140978
Abstract: ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with… read more here.
Keywords: zip8 a391t; disease; zip8; manganese homeostasis ... See more keywords
Divalent Metal Uptake and the Role of ZIP8 in Host Defense Against Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.924820
Abstract: Manganese (Mn) and Zinc (Zn) are essential micronutrients whose concentration and location within cells are tightly regulated at the onset of infection. Two families of Zn transporters (ZIPs and ZnTs) are largely responsible for regulation… read more here.
Keywords: zip8; metal uptake; host defense; host ... See more keywords
Single-gene knockout-coupled omics analysis identifies C9orf85 and CXorf38 as two uncharacterized human proteins associated with ZIP8 malfunction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.991308
Abstract: Human transmembrane protein metal cation symporter ZIP8 (SLC39A8) is a member of the solute carrier gene family responsible for intracellular transportation of essential micronutrients, including manganese, selenium, and zinc. Previously, we established a ZIP8-knockout (KO)… read more here.
Keywords: zip8; essential micronutrients; knockout; analysis ... See more keywords
The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.912277
Abstract: The metal ion transporter ZIP8 (SLC39A8) mediates cellular uptake of vital divalent metal ions. Genome-wide association studies (GWAS) showed that the single-nucleotide polymorphism (SNP) variant A391T (rs13107325) is associated with numerous human traits, including reduced… read more here.
Keywords: metal ion; ion transporter; zip8;
Generation of a Polyclonal Antibody against the Mouse Metal Transporter ZIP8
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DOI: 10.3390/antib10020016
Abstract: ZIP8 is a newly identified metal transporter. In human patients, mutations in ZIP8 result in severe manganese deficiency, suggesting a critical role for ZIP8 in regulating systemic manganese homeostasis. In mice, the deletion of ZIP8… read more here.
Keywords: zip8; metal transporter; antibody; mouse ... See more keywords
The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization
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DOI: 10.3390/ijms222111399
Abstract: The metal cation symporter ZIP8 (SLC39A8) is a transmembrane protein that imports the essential micronutrients iron, manganese, and zinc, as well as heavy toxic metal cadmium (Cd). It has been recently suggested that selenium (Se),… read more here.
Keywords: g204c s335t; zip8; cadmium; selenium ... See more keywords
TGF-β1 Potentiates the Cytotoxicity of Cadmium by Induction of a Metal Transporter, ZIP8, Mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK Signal Pathways in Cultured Vascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010448
Abstract: Vascular endothelial cells cover the luminal surface of blood vessels in a monolayer and play a role in the regulation of vascular functions, such as the blood coagulation-fibrinolytic system. When the monolayer is severely or… read more here.
Keywords: vascular endothelial; zip8; cadmium; cytotoxicity ... See more keywords
The Regulation of ZIP8 by Dietary Manganese in Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065962
Abstract: ZIP8 is a newly identified manganese transporter. A lack of functional ZIP8 results in severe manganese deficiency in both humans and mice, indicating that ZIP8 plays a crucial role in maintaining body manganese homeostasis. Despite… read more here.
Keywords: dietary manganese; zip8; high manganese; mice ... See more keywords