Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2016.12.008
Abstract: Abstract Intracellular retinal iron accumulation has been implicated in the pathogenesis of age‐related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO)… read more here.
Keywords: zip8 zip14; retinal iron; zip14; iron ... See more keywords
The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis
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DOI: 10.3390/ijms21093304
Abstract: As an essential nutrient, manganese is required for the regulation of numerous cellular processes, including cell growth, neuronal health, immune cell function, and antioxidant defense. However, excess manganese in the body is toxic and produces… read more here.
Keywords: homeostasis; zip8 zip14; znt10; manganese homeostasis ... See more keywords
HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes
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DOI: 10.3390/ijms22126349
Abstract: Intracellular free zinc ([Zn2+]i) is mobilized in neuronal and non-neuronal cells under physiological and/or pathophysiological conditions; therefore, [Zn2+]i is a component of cellular signal transduction in biological systems. Although several transporters and ion channels that… read more here.
Keywords: zip8 zip14; zn2; expression; trpa1 ... See more keywords