Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation
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DOI: 10.1038/s41598-020-66377-z
Abstract: Autophagy is an essential cellular process that maintains homeostasis by recycling damaged organelles and nutrients during development and cellular stress. ZKSCAN3 is the sole identified master transcriptional repressor of autophagy in human cell lines. How… read more here.
Keywords: m1bp functionally; m1bp; zkscan3; drosophila m1bp ... See more keywords
ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
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DOI: 10.1093/nar/gkaa425
Abstract: Abstract Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is… read more here.
Keywords: heterochromatin; senescence; zkscan3; cellular senescence ... See more keywords
Cardiomyocyte ZKSCAN3 regulates remodeling following pressure‐overload
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DOI: 10.14814/phy2.15686
Abstract: Autophagy is important for protein and organelle quality control. Growing evidence demonstrates that autophagy is tightly controlled by transcriptional mechanisms, including repression by zinc finger containing KRAB and SCAN domains 3 (ZKSCAN3). We hypothesize that… read more here.
Keywords: zkscan3; z3k; tac; mice ... See more keywords