Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation
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DOI: 10.1038/s41598-020-66377-z
Abstract: Autophagy is an essential cellular process that maintains homeostasis by recycling damaged organelles and nutrients during development and cellular stress. ZKSCAN3 is the sole identified master transcriptional repressor of autophagy in human cell lines. How… read more here.
Keywords: m1bp functionally; m1bp; zkscan3; drosophila m1bp ... See more keywords
ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
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DOI: 10.1093/nar/gkaa425
Abstract: Abstract Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is… read more here.
Keywords: heterochromatin; senescence; zkscan3; cellular senescence ... See more keywords
Expression of ZKSCAN3 protein suppresses proliferation, migration, and invasion of pancreatic cancer through autophagy
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DOI: 10.1111/cas.16173
Abstract: Elevated autophagy activity enhances the malignancy of pancreatic cancer (PaCa), and autophagy is recognized as a novel therapeutic target. Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) is a transcription factor that suppresses… read more here.
Keywords: zkscan3; pancreatic cancer; paca; proliferation ... See more keywords
Cardiomyocyte ZKSCAN3 regulates remodeling following pressure‐overload
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DOI: 10.14814/phy2.15686
Abstract: Autophagy is important for protein and organelle quality control. Growing evidence demonstrates that autophagy is tightly controlled by transcriptional mechanisms, including repression by zinc finger containing KRAB and SCAN domains 3 (ZKSCAN3). We hypothesize that… read more here.
Keywords: zkscan3; z3k; tac; mice ... See more keywords
ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2025.1623062
Abstract: Ovarian cancer has the worst prognosis among major gynecological cancers. Current therapies include platinum, Taxol, angiogenesis inhibitors, and poly[ADP-ribose]polymerase (PARP) inhibitors. However, resistance develops in most ovarian cancer patients. Identification of more pro-tumor factors in… read more here.
Keywords: cell proliferation; zkscan3; ovarian cancer; cancer ... See more keywords