ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24068
Abstract: New strategies must be developed to resolve the problems of stroke treatment. In recent years, stem cell–based therapy after stroke has come into the public and academic lens. Previously we have shown that uncoupling neuronal… read more here.
Keywords: male rats; differentiation; zl006; stem cells ... See more keywords
An Injectable Hydrogel for Treatment of Chronic Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100529
Abstract: Current treatments for chronic neuropathic pain often fall short. A small-molecular compound ZL006 can suppress N-Methyl-D-aspartate receptor (NMDAR)-mediated neuropathic pain behaviors without blocking essential NMDAR function and brings new hope for neuropathic pain therapy. The… read more here.
Keywords: injectable hydrogel; zl006; pain; neuropathic pain ... See more keywords
P.2.032 ZL006 has antidepressant effects and attenuates changes in dendritic spines associated with astrocytic impairment in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.071
Abstract: The NMDA receptor (NMDA-R) remains a promising target for treating CNS disorders including depression. Directly targeting NMDA-R is however liable to produce unwanted adverse effects. Previous studies demonstrate that nitric oxide (NO) synthase inhibitors are… read more here.
Keywords: depression; mice; changes dendritic; zl006 ... See more keywords
A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABAARs
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.58364
Abstract: Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) in the setting of injury represents a key mechanism of neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction between postsynaptic… read more here.
Keywords: tolerance; nnos psd; interaction; analgesic tolerance ... See more keywords