ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis
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DOI: 10.1016/j.celrep.2018.03.132
Abstract: SUMMARY Post-translational modification of ribosomal subunit proteins (RPs) is emerging as an important means of regulating gene expression. Recently, regulatory ubiquitination of small RPs RPS10 and RPS20 by the ubiquitin ligase ZNF598 was found to… read more here.
Keywords: znf598; poxvirus; gene expression; expression ... See more keywords
GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.
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DOI: 10.1016/j.celrep.2019.03.006
Abstract: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and the translation inhibitory complex… read more here.
Keywords: regulation inflammatory; znf598; inflammatory signaling; regulation ... See more keywords
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs
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DOI: 10.1038/ncomms16056
Abstract: Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent peptide degradation are well-understood, the… read more here.
Keywords: protein; ubiquitin ligase; znf598; rna binding ... See more keywords