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   Articles with "znf598" as a keyword



ZNF598 Plays Distinct Roles in Interferon-Stimulated Gene Expression and Poxvirus Protein Synthesis

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.03.132

Abstract: SUMMARY Post-translational modification of ribosomal subunit proteins (RPs) is emerging as an important means of regulating gene expression. Recently, regulatory ubiquitination of small RPs RPS10 and RPS20 by the ubiquitin ligase ZNF598 was found to… read more here.

Keywords: znf598; poxvirus; gene expression; expression ... See more keywords
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GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

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recommendations! Published in 2019 at "Cell reports"

DOI: 10.1016/j.celrep.2019.03.006

Abstract: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and the translation inhibitory complex… read more here.

Keywords: regulation inflammatory; znf598; inflammatory signaling; regulation ... See more keywords

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms16056

Abstract: Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent peptide degradation are well-understood, the… read more here.

Keywords: protein; ubiquitin ligase; znf598; rna binding ... See more keywords

Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-45525-3

Abstract: Translational control exerts immediate effect on the composition, abundance, and integrity of the proteome. Ribosome-associated quality control (RQC) handles ribosomes stalled at the elongation and termination steps of translation, with ZNF598 in mammals and Hel2… read more here.

Keywords: quality control; translation; stalled translation; znf598 ... See more keywords

Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae087

Abstract: Abstract Ribosomal stalling induces the ribosome-associated quality control (RQC) pathway targeting aberrant polypeptides. RQC is initiated by K63-polyubiquitination of ribosomal protein uS10 located at the mRNA entrance of stalled ribosomes by the E3 ubiquitin ligase… read more here.

Keywords: prerequisite; ubiquitination; ribosomal collision; mediated ribosome ... See more keywords