Zoledronate promotes osteoblast differentiation in high‐glucose conditions via the p38MAPK pathway
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DOI: 10.1002/cbin.11921
Abstract: Zoledronate (ZOL) were found to inhibit bone resorption in an animal model of diabetes, high glucose concentrations have been shown to decreased the osteogenesis‐related gene expression. But the molecular mechanism by which high glucose levels… read more here.
Keywords: expression; high glucose; differentiation; osteoblast differentiation ... See more keywords
Treatment With Zoledronate Subsequent to Denosumab in Osteoporosis: A 2‐Year Randomized Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4305
Abstract: Increased bone turnover and rapid bone loss follow discontinuation of denosumab. We investigated the long‐term efficacy of zoledronate (ZOL) in maintaining bone mineral density (BMD) after discontinuation of denosumab. In this randomized, open‐label, interventional study,… read more here.
Keywords: year; denosumab; group; bone ... See more keywords
Comparative Effect of Zoledronate at 6 Versus 18 Months Following Denosumab Discontinuation.
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DOI: 10.1007/s00223-020-00785-1
Abstract: Discontinuation of denosumab treatment is associated with rapid bone loss that could be prevented in many patients by zoledronate (ZOL) infusion given 6 months after the last denosumab injection. The effects, however, of zoledronate administration… read more here.
Keywords: versus months; early zol; zol infusion; zol ... See more keywords
Adjuvant zoledronic acid reduces fractures in breast cancer patients; an AZURE (BIG 01/04) study.
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DOI: 10.1016/j.ejca.2018.02.004
Abstract: The fracture impact of adjuvant bisphosphonates in breast cancer is not defined with most trials reporting changes in bone mineral density as a surrogate. The AZURE trial (ISRCTN79831382) evaluated the impact of adjuvant zoledronic acid… read more here.
Keywords: zoledronic acid; fracture; adjuvant zoledronic; breast cancer ... See more keywords
Effects of follow-on therapy after denosumab discontinuation in patients with postmenopausal osteoporosis
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DOI: 10.1080/14397595.2020.1769895
Abstract: Abstract Objectives To clarify the effects of follow-on therapy after denosumab (DMAb) discontinuation. Methods In this retrospective, multicenter study, postmenopausal patients with osteoporosis who were previously treated by oral bisphosphonates (BP) (n = 26) or teriparatide (TPTD)… read more here.
Keywords: follow therapy; dmab; effects follow; discontinuation ... See more keywords
Acute Cognitive Effects of the Hypocretin Receptor Antagonist Almorexant Relative to Zolpidem and Placebo: A Randomized Clinical Trial.
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DOI: 10.1093/sleep/zsaa080
Abstract: STUDY OBJECTIVES Hypnotic medications can adversely affect behavior during unanticipated awakenings during the night. Animals treated with the hypocretin receptor antagonist almorexant (ALM) have less acute cognitive impairment compared to the GABAA receptor modulator zolpidem… read more here.
Keywords: receptor antagonist; hypocretin receptor; acute cognitive; antagonist almorexant ... See more keywords
0351 Differential Effect of Lemborexant and Zolpidem on Wake Across the Night in Patients with Insomnia Disorder
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DOI: 10.1093/sleep/zsad077.0351
Abstract: Insomnia can involve difficulty with falling and/or staying asleep; older adults tend to report more sleep maintenance issues. While zolpidem tartrate extended-release 6.25mg (ZOL) is indicated to treat sleep onset and maintenance, data indicate that… read more here.
Keywords: nt1 nt29; pbo; wake; cfb ... See more keywords
0354 Effect of Lemborexant on Sleep Architecture in Subjects with Comorbid Insomnia and Mild Obstructive Sleep Apnea from a Ph 3 Trial
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DOI: 10.1093/sleep/zsad077.0354
Abstract: Many patients with insomnia have co-morbid obstructive sleep apnea (COMISA). Patients with obstructive sleep apnea (OSA) may also have decreased REM-sleep. Lemborexant (LEM) is a dual-orexin-receptor-antagonist approved to treat adults with insomnia. LEM has been… read more here.
Keywords: zol pbo; lem; apnea; zol ... See more keywords
Zoletil promotes apoptosis in BV-2 microglial cells via induction of oxidative stress and neural inflammation.
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DOI: 10.1093/toxres/tfab115
Abstract: Zoletil® (ZOL) is a combination drug of tiletamine, a dissociative anesthetic and zolazepam, a minor tranquilize, which has been used to induce short-term anesthesia in various animals. Depending on the administered dose, the effects of… read more here.
Keywords: zol; microglial cells; zoletil promotes; oxidative stress ... See more keywords
Acute Cognitive Effects of the Dual Orexin Receptor Antagonist Lemborexant Compared With Suvorexant and Zolpidem in Recreational Sedative Users
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001562
Abstract: Abstract Purpose/Background As part of a human abuse potential (HAP) study of lemborexant (LEM), the effects of therapeutic (LEM 10 mg), and supratherapeutic doses of LEM 20 mg and LEM 30 mg on cognition and… read more here.
Keywords: suv; lem; reaction; reaction time ... See more keywords
Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis
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DOI: 10.1111/odi.13052
Abstract: Abstract Objectives To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue‐level features of… read more here.
Keywords: bronj like; prevalence; duration; zol ... See more keywords