Preclinical support for the therapeutic potential of zolmitriptan as a treatment for cocaine use disorders
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-00956-6
Abstract: Serotonin 1B receptor (5-HT 1B R) agonists enhance cocaine intake in rats during daily self-administration but attenuate cocaine intake after prolonged abstinence. Here we investigated whether the less selective but clinically available 5-HT 1D/1B R… read more here.
Keywords: zolmitriptan; treatment cocaine; cocaine use; cocaine intake ... See more keywords
Development of zolmitriptan transfersomes by Box–Behnken design for nasal delivery: in vitro and in vivo evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2017.1402918
Abstract: Abstract The aim was to prepare an optimized zolmitriptan (ZT)-loaded transfersome formulation using Box–Behnken design for improving the bioavailability by nasal route for quick relief of migraine and further to compare with a marketed nasal… read more here.
Keywords: box behnken; zolmitriptan; behnken design; drug ... See more keywords
Evaluation of Brain Targeting Potential of Zolmitriptan Mucoadhesive Nanoparticles for Intranasal Drug Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738510666220303160414
Abstract: BACKGROUND Hydrophilic drugs are poor applicants of brain targeting via oral route due to the presence of blood-brain barrier that allows only small lipophilic molecules to freely access the brain. Due to unique anatomical connections… read more here.
Keywords: brain targeting; brain; drug delivery; drug ... See more keywords