Obesity results with smaller oocyte in in vitro fertilization/intracytoplasmic sperm injection cycles—a prospective study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-017-0975-6
Abstract: BackgroundObesity is associated with several fertility disorders. This prospective cohort study was designed to evaluate the effect of body mass index (BMI) (kg/m2) on oocyte diameter and treatment.MethodsWomen undergoing in vitro fertilization (IVF) with intracytoplasmic… read more here.
Keywords: intracytoplasmic sperm; sperm injection; vitro fertilization; study ... See more keywords
A novel homozygous nonsense mutation in zona pellucida 1 (ZP1) causes human female empty follicle syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02136-x
Abstract: To identify a pathogenic gene mutation in a female infertility proband characterized by empty follicle syndrome (EFS) and explore the genetic cause of EFS. Whole exome sequencing (WES) was performed to identify the candidate pathogenic… read more here.
Keywords: zp1; empty follicle; mutation; zona pellucida ... See more keywords
Efficient production of human zona pellucida-3 in a prokaryotic expression system
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-018-2521-9
Abstract: The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. We aimed to produce a recombinant ZP3 peptide using the Escherichia coli secretory system and apply it to a protein chip… read more here.
Keywords: protein chip; zp3; system; zona pellucida ... See more keywords
Characterization of a mutation in the zona pellucida module of Endoglin that causes Hereditary Hemorrhagic Telangiectasia.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.016
Abstract: Hereditary hemorrhagic telangiectasia (HHT) is a vascular rare disease characterized by nose and gastrointestinal bleeding, skin and mucosa telangiectasias, and arteriovenous malformations in internal organs. HHT shows an autosomal dominant inheritance and a worldwide prevalence… read more here.
Keywords: mutation; hereditary hemorrhagic; pellucida module; hemorrhagic telangiectasia ... See more keywords
Type 1 diabetes affects zona pellucida and genome methylation in oocytes and granulosa cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110627
Abstract: Diabetes affects oocyte nuclear and cytoplasmic quality. In this study, we generated a type 1 diabetes (T1D) mouse model by STZ injection to study the effects of T1D on zona pellucida and genomic DNA methylation… read more here.
Keywords: granulosa cells; methylation; oocytes granulosa; type diabetes ... See more keywords
Zona pellucida blocks adenovirus from entering porcine oocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.03.008
Abstract: Adenovirus is a kind of non-enveloped,double-stranded DNA virus. As a member of the mammalian adenoviruses of the Adenoviridae family, porcine adenovirus causes gastrointestinal disease in piglets. In this study, the modified adenovirus was manipulated to… read more here.
Keywords: porcine oocytes; modified adenovirus; zona pellucida; porcine ... See more keywords
An Alternative Way to Improve Mammalian Embryo Development In Vitro: Culture of Zona Pellucida-Free Embryos.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular reprogramming"
DOI: 10.1089/cell.2022.0012
Abstract: An increasing number of data proves that the presence of the zona pellucida is not essential to mammalian embryo production, including maturation, fertilization, and embryo culture. In fact, the structure of the zona pellucida of… read more here.
Keywords: culture; zona pellucida; zona; free embryos ... See more keywords
Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats†
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab025
Abstract: Abstract The zona pellucida (ZP) plays vital roles in reproductive processes including oogenesis, fertilization, and preimplantation development. Both human and rat ZP consist of four glycoproteins, called ZP1, ZP2, ZP3, and ZP4. Our previous research… read more here.
Keywords: infertility; zp1; zp3 zp4; zona pellucida ... See more keywords
Zona pellucida removal by acid Tyrode's solution affects pre- and post-implantation development and gene expression in mouse embryos
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac155
Abstract: Abstract The zona pellucida plays a crucial role in the process of fertilization to early embryonic development, including cellular arrangement and communication between blastomeres. However, little is known regarding the role of the zona pellucida… read more here.
Keywords: post implantation; development; zona; zona pellucida ... See more keywords
Initial detachment of the mouse oocyte from the zona pellucida is mediated by metallopeptidase activity
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac185
Abstract: Abstract The fully grown mammalian oocyte is tightly attached to its extracellular matrix shell, the zona pellucida (ZP), but the oocyte detaches from the ZP shortly after ovulation is signaled. The mechanism by which the… read more here.
Keywords: metallopeptidase activity; zona pellucida; oocyte; mouse oocyte ... See more keywords
ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction"
DOI: 10.1093/humrep/dead059
Abstract: STUDY QUESTION Does a homozygous nonsense mutation in ACR lead to total fertilization failure (TFF) resulting in male infertility in humans? SUMMARY ANSWER A novel homozygous nonsense mutation of ACR (c.167G>A, p.Trp56X) was identified in… read more here.
Keywords: acrosin; fertilization; fertilization failure; acrosin deficiency ... See more keywords