Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817298116
Abstract: Significance Pregnancy is a unique physiological state involving biological stresses that promote protein damage (misfolding) within the maternal body. Currently, little is known regarding how the maternal body copes with elevated protein misfolding in pregnancy.… read more here.
Keywords: pregnancy; misfolded proteins; zone protein; pzp ... See more keywords
Circulatory cytokeratin 17, marginal zone B1 protein and leucine-rich α2-glycoprotein-1 as biomarkers for disease severity and fibrosis in systemic sclerosis patients
Sign Up to like & getrecommendations! Published in 2022 at "Biochemia Medica"
DOI: 10.11613/bm.2022.030707
Abstract: Introduction Systemic sclerosis (Ssc) is a multiorgan debilitating autoimmune disease that associates the triad: vascular involvement, tissue fibrosis and profound immune response alterations. Numerous previous studies focused on identification of candidate proteomic Ssc biomarkers using… read more here.
Keywords: systemic sclerosis; leucine rich; rich glycoprotein; marginal zone ... See more keywords
The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002030
Abstract: Autophagy is essential for cellular homeostasis and function. In neurons, autophagosome biogenesis is temporally and spatially regulated to occur near presynaptic sites, in part via the trafficking of autophagy transmembrane protein ATG-9. The molecules that… read more here.
Keywords: sorting atg; active zone; presynaptic autophagy; zone ... See more keywords
Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.950619
Abstract: The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account for this.… read more here.
Keywords: intermittent fasting; pregnancy zone; pzp; zone protein ... See more keywords