Comparison of performance characteristics between high‐performance liquid chromatography and latex agglutination turbidimetric immunoassay for therapeutic drug monitoring of zonisamide
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22940
Abstract: Recently, the Nanopia® TDM Zonisamide reagent using the latex particle‐enhanced turbidimetric immunoassay (LTIA) method was developed. The aim of this study was to compare the differences in serum zonisamide (ZNS) concentrations quantified by the high‐performance… read more here.
Keywords: zonisamide; turbidimetric immunoassay; liquid chromatography; performance ... See more keywords
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.07.005
Abstract: Abstract Parkinson's disease (PD), the second most common age‐related progressive neurodegenerative disorder, is characterized by dopamine depletion and the loss of dopaminergic (DA) neurons with accompanying neuroinflammation. Zonisamide is an‐anti‐convulsant drug that has recently been… read more here.
Keywords: zonisamide reduces; zonisamide; microglial nav; drug ... See more keywords
Zonisamide Therapy for Patients With Paroxysmal Kinesigenic Dyskinesia.
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2020.06.017
Abstract: BACKGROUND We evaluated zonisamide therapy in patients with paroxysmal kinesigenic dyskinesia (PKD). METHODS We analyzed zonisamide therapy in 17 patients with PKD at Saitama Children's Medical Center between November 1994 and April 2020. We collected… read more here.
Keywords: commencement; zonisamide therapy; zonisamide; therapy patients ... See more keywords
Neuroinflammation following anti-parkinsonian drugs in early Parkinson’s disease: a longitudinal PET study
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-55233-z
Abstract: The progression of neuroinflammation after anti-parkinsonian therapy on the Parkinson’s disease (PD) brain and in vivo evidence of the therapy purporting neuroprotection remain unclear. To elucidate this, we examined changes in microglial activation, nigrostriatal degeneration,… read more here.
Keywords: zonisamide; zonisamide group; therapy; pet ... See more keywords
Effect of topiramate and zonisamide on fMRI cognitive networks
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DOI: 10.1212/wnl.0000000000003736
Abstract: Objective: To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. Methods: In a retrospective, cross-sectional study, we identified… read more here.
Keywords: tpm; cognitive networks; tpm zns; zns ... See more keywords
The effect of oral zonisamide treatment on serum phenobarbital concentrations in epileptic dogs
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2024.1389615
Abstract: Zonisamide is used in dogs for the treatment of epileptic seizures. It is predominantly metabolised by CYP450 hepatic enzymes. When used concurrently with phenobarbital (PB), zonisamide clearance is increased and its elimination half-life decreases. However,… read more here.
Keywords: zonisamide; serum concentrations; effect oral; treatment ... See more keywords
Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154899
Abstract: In this research, a UHPLC–MS/MS method was developed and validated for the determination of zonisamide in dried plasma spots (DPS) and dried blood spots (DBS). Detection of zonisamide and internal standard, 1-(2,3-dichlorphenyl)piperazine, was carried out… read more here.
Keywords: zonisamide; dried plasma; dried blood; blood ... See more keywords