Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1506-8
Abstract: A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1)… read more here.
Keywords: connexin43 mimetic; zonula occludens; ct1; rpe pathophysiology ... See more keywords
Zonula occludens-1 demonstrates a unique appearance in buccal mucosa over several layers.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03425-8
Abstract: Tight junctions (TJs) firmly seal epithelial cells and are key players in the epithelial barrier. TJs consist of several proteins, including those of the transmembrane claudin family and the scaffold zonula occludens (ZO) family. Epithelial… read more here.
Keywords: buccal mucosa; appearance buccal; zonula occludens; barrier function ... See more keywords
Zonula occludens-1 distribution and barrier functions are affected by epithelial proliferation and turnover rates.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13441
Abstract: Zonula occludens-1 (ZO-1) is a scaffolding protein of tight junctions, which seal adjacent epithelial cells, that is also expressed in adherens junctions. The distribution pattern of ZO-1 differs among stratified squamous epithelia, including that between… read more here.
Keywords: zonula occludens; proliferation; squamous epithelia; affected epithelial ... See more keywords
Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4484-5
Abstract: BackgroundHepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (TJ)… read more here.
Keywords: protein; hcc; inflammation; hcc patients ... See more keywords
Role of zonula occludens in gastrointestinal and liver cancers
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i12.3647
Abstract: A growing body of evidence suggests that tight junction (TJ) proteins play a crucial role in the pathogenesis of various diseases, including gastrointestinal (GI) cancer and hepatocellular carcinoma (HCC). TJ proteins primarily maintain the epithelial… read more here.
Keywords: zonula occludens; role; liver cancers; hcc ... See more keywords