Structural basis of ZP2-targeted female nonhormonal contraception
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2426057122
Abstract: Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an IE-3-derived single-chain variable fragment (scFV) is sufficient for blocking fertilization in vitro and… read more here.
Keywords: zp2; structural basis; zp2 targeted; targeted female ... See more keywords
Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.
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DOI: 10.1093/humrep/deac026
Abstract: STUDY QUESTION Is a recurrent heterozygous mutation in ZP2, c.1925G>A (p.R642Q), associated with the Empty follicle syndrome (EFS)? SUMMARY ANSWER ZP2, c.1925G>A (p.R642Q), led to female infertility related to EFS in humans and mice and… read more here.
Keywords: mutation zp2; zp2r642q; mice; zp2 ... See more keywords
O-291 New facets of zona pellucida (ZP) proteins: called oocyte-specific, yet produced by the preimplantation embryo and needed for blastocyst formation
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DOI: 10.1093/humrep/deaf097.291
Abstract: What does a secreted oocyte-specific protein, ZP2, do inside mouse embryos during cleavage? Contrary to prevalent notion, ZP2 protein synthesis is not silenced after ovulation, but goes on in preimplantation embryos to support the morula-blastocyst… read more here.
Keywords: zp2; blastocyst; zona pellucida; protein ... See more keywords