Yunpi Heluo decoction attenuates insulin resistance by regulating liver miR-29a-3p in Zucker diabetic fatty rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.111966
Abstract: BACKGROUND AND OBJECTIVE Yunpiheluo (YPHL) decoction is a Chinese herbal formula with unique advantages for the treatment of type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate changes in miRNA… read more here.
Keywords: zucker diabetic; diabetic fatty; decoction; mir 29a ... See more keywords
Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats
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DOI: 10.1016/j.jff.2020.103981
Abstract: Abstract The beneficial effects of rice bran protein (RBP), which comprises 12.8% of rice bran, have not been fully characterized. Therefore, the effects of RBP on diabetes, fatty liver, and diabetic nephropathy were investigated in… read more here.
Keywords: zucker diabetic; diabetic fatty; fatty liver; bran protein ... See more keywords
Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13733
Abstract: Diabetic coronary artery injury is closely associated with Ca2+ dysregulation, although the underlying mechanism remains unclear. This study explored the role and mechanism of Ca2+ handling in coronary artery dysfunction in type 2 diabetic rats.… read more here.
Keywords: calcium; artery; zucker diabetic; zdf rats ... See more keywords
Zucker Diabetic‐Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model
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DOI: 10.1113/ep089947
Abstract: What is the topic of this review? The Zucker Diabetic‐Sprague Dawley (ZDSD) rat is in the early adoption phase of use by researchers in the fields of diabetes, including prediabetes, obesity and metabolic syndrome. It… read more here.
Keywords: sprague dawley; zdsd; zucker diabetic; dawley zdsd ... See more keywords
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats
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DOI: 10.2337/db16-0916
Abstract: Neurturin (NRTN), a member of the glial-derived neurotrophic factor family, was identified from an embryonic chicken pancreatic cDNA library in a screen for secreted factors. In this study, we assessed the potential antidiabetic activities of… read more here.
Keywords: zucker diabetic; zdf rats; diabetic fatty; neurturin glp ... See more keywords
Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle
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DOI: 10.2337/db16-1410
Abstract: Ten-week-old Zucker diabetic fatty (ZDF) rats at an early stage of diabetes embody metabolic characteristics of obese human patients with type 2 diabetes, such as severe insulin and glucose intolerance in muscle and the liver,… read more here.
Keywords: zucker diabetic; diabetic fatty; glucose effectiveness; muscle ... See more keywords
The impact of diabetes mellitus type 2 on the steroidogenesis of male Zucker Diabetic Fatty rats.
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DOI: 10.33549/physiolres.934881
Abstract: The aim of this study was to evaluate the impact of diabetes mellitus type 2 (DM2) on the male endocrine system of Zucker Diabetic Fatty (ZDF) rats. Sexually mature ZDF rats were divided to a… read more here.
Keywords: diabetic fatty; zucker diabetic; mellitus type; diabetes mellitus ... See more keywords
Dynamic Development of Fecal Microbiome During the Progression of Diabetes Mellitus in Zucker Diabetic Fatty Rats
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DOI: 10.3389/fmicb.2019.00232
Abstract: Background: Although substantial efforts have been made to link the gut microbiota to type 2 diabetes, dynamic changes in the fecal microbiome under the pathological conditions of diabetes have not been investigated. Methods: Four male… read more here.
Keywords: zucker diabetic; diabetic fatty; diversity; microbiome ... See more keywords
The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1043275
Abstract: Cannabidiol (CBD), the most extensively studied non-intoxicating phytocannabinoid, has been attracting a lot of interest worldwide owing to its numerous beneficial effects. The aim of this study was to explore the effect that CBD exerts… read more here.
Keywords: cbd; diabetic fatty; adenosine; zucker diabetic ... See more keywords
The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.827033
Abstract: The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes and cardiovascular… read more here.
Keywords: male zucker; empagliflozin; zucker diabetic; inhibitor empagliflozin ... See more keywords
Alterations of the Ca2+ clearing mechanisms by type 2 diabetes in aortic smooth muscle cells of Zucker diabetic fatty rat
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1200115
Abstract: Type 2 Diabetes Mellitus (T2DM) is a rapidly rising disease with cardiovascular complications constituting the most common cause of death among diabetic patients. Chronic hyperglycemia can induce vascular dysfunction through damage of the components of… read more here.
Keywords: muscle cells; diabetic fatty; zucker diabetic; type diabetes ... See more keywords