Physicochemical Properties of Zwitterionic Drugs in Therapy
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000164
Abstract: In solution, amphoteric compounds exist in anionic, uncharged, zwitterionic and cationic forms. The importance of zwitterionic drugs is currently under‐represented in the literature. Herein, the acid‐base parameters, lipophilicity and solubility of such compounds are discussed… read more here.
Keywords: zwitterionic drugs; properties zwitterionic; physicochemical properties; drugs therapy ... See more keywords
Application of Population Balance Model to Simulate Precipitation of Weak Base and Zwitterionic Drugs in Gastrointestinal pH Environment.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00088
Abstract: The purpose of the present study was to evaluate whether the population balance model (PBM) could be a suitable model for the precipitation of weak base and zwitterionic drugs in the gastrointestinal pH environment. Five… read more here.
Keywords: weak base; zwitterionic drugs; model; base zwitterionic ... See more keywords