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Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22926
Abstract: The maternal‐zygotic transition (MZT) describes the developmental reprogramming of gene expression marked by the degradation of maternally supplied gene products and activation of the zygotic genome. While the timing and duration of the MZT vary…
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Keywords:
eight cell;
maternal zygotic;
zygotic transition;
cell stage ... See more keywords
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Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.004
Abstract: Upon fertilization, oocytes transform into totipotent and pluripotent cleavage stage cells through the maternal-to-zygotic transition (MZT), which is regulated by maternal factors and zygotic genome activation (ZGA). Here, we investigated the in vivo function of 16…
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Keywords:
gene family;
five multicopy;
multicopy gene;
maternal zygotic ... See more keywords
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Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107783
Abstract: SUMMARY In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents more than half of the protein-coding capacity of Drosophila melanogaster’s genome,…
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Keywords:
transcriptional repressors;
post transcriptional;
maternal zygotic;
zygotic transition ... See more keywords
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Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.10.005
Abstract: The zygotic transition, from a fertilized egg to an embryo, is central to animal and plant reproduction. Animal embryos depend upon maternally provided factors until zygotic genome activation (ZGA). In plants, the timing and parental…
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Keywords:
parental genomes;
plant;
zygotic transition;
activation ... See more keywords
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Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.10.036
Abstract: The maternal genome directs almost all aspects of early animal development. As development proceeds, the elimination of maternal gene products and zygotic genome activation (ZGA) occur during the maternal to zygotic transition (MZT). To study…
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Keywords:
sinensis;
early embryogenesis;
maternal zygotic;
zygotic transition ... See more keywords
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Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114699
Abstract: Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being…
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Keywords:
target niclosamide;
embryogenesis;
maternal zygotic;
zygotic transition ... See more keywords
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Published in 2020 at "Nature cell biology"
DOI: 10.1038/s41556-020-0494-z
Abstract: The importance of germline-inherited post-translational histone modifications on priming early mammalian development is just emerging 1 – 4 . Histone H3 lysine 9 (H3K9) trimethylation is associated with heterochromatin and gene repression during cell-fate change…
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Keywords:
broad h3k4me3;
maternal zygotic;
zygotic transition;
kdm4a ... See more keywords
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Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0008-z
Abstract: A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling, genome spatial reorganization and substantial transcriptional changes. Key to these changes is the…
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Keywords:
transition;
chromatin;
maternal zygotic;
landscape ... See more keywords
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1
Published in 2022 at "Fly"
DOI: 10.1080/19336934.2022.2043095
Abstract: ABSTRACT Downregulation of protein phosphatase Cdc25Twine activity is linked to remodelling of the cell cycle during the Drosophila maternal-to-zygotic transition (MZT). Here, we present a structure-function analysis of Cdc25Twine. We use chimeras to show that…
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Keywords:
drosophila maternal;
structure function;
cdc25twine;
zygotic transition ... See more keywords
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Published in 2022 at "Fly"
DOI: 10.1080/19336934.2022.2139981
Abstract: ABSTRACT The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which…
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Keywords:
notch signaling;
zygotic transition;
notch signalling;
maternal zygotic ... See more keywords
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Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08114-y
Abstract: Background Maternal mRNA provisioning of oocytes regulates early embryogenesis. Maternal transcripts are degraded as zygotic genome activation (ZGA) intensifies, a phenomenon known as the maternal-to-zygotic transition (MZT). Here, we examine gene expression over nine developmental…
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Keywords:
maternal zygotic;
maternal mrna;
zygotic transition;
mrna provisioning ... See more keywords