Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
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DOI: 10.1080/14756366.2021.2024527
Abstract: Abstract Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is… read more here.
Keywords: highly potent; zymogen like; catk; differently positioned ... See more keywords