The cytoskeletal protein Zyxin interacts with the zinc-finger transcription factor Zic1 and plays the role of a scaffold for Gli1 and Zic1 interactions during early development of Xenopus laevis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.164
Abstract: We have shown recently that the cytoskeletal protein Zyxin participates in the fine tuning of the neural plate pattering in Xenopus laevis embryos by modulating activity of one of the effectors of Hedgehog (Shh) signaling… read more here.
Keywords: gli1 zic1; transcription factor; zyxin; zic1 ... See more keywords
Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction
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DOI: 10.1371/journal.pgen.1010319
Abstract: One of the most common cell shape changes driving morphogenesis in diverse animals is the constriction of the apical cell surface. Apical constriction depends on contraction of an actomyosin network in the apical cell cortex,… read more here.
Keywords: cell; apical constriction; actomyosin networks; cell junctions ... See more keywords
Zyxin and Actin Structure Confer Anisotropic YAP Mechanotransduction.
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DOI: 10.2139/ssrn.4040745
Abstract: Tissues and the embedded cells experience anisotropic deformations due to their functions and anatomical locations. The resident cells, such as tenocytes and muscle cells, are often restricted by their extracellular matrix and organize parallel to… read more here.
Keywords: structure; stretch; anisotropic yap; focal adhesion ... See more keywords
Zyxin: a mechanotransductor to regulate gene expression.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201901_16790
Abstract: OBJECTIVE Cells answer to biochemical, electrical and mechanical signals in the environment, which regulate their behavior. Mechanical signals can propagate through mechanically stiff structures like focal adhesions (FAs). Zyxin, a LIM domain protein, is localized… read more here.
Keywords: mechanotransductor regulate; gene expression; regulate gene; zyxin ... See more keywords