LAUSR

Reactive oxygen species (ROS) production efficiencies of the nanocatalysts are highly desired for cancer therapy, but currently the ROS generation efficiency is still far from defecting the tumors. Therefore, improving their ROS generation ability is highly desirable for cancer therapy. Herein, inspired by the electrostatic preorganization effect during the catalysis of natural protein enzymes, a human self‐driven catalysis‐promoting system, TENG‐CatSystem is developed, to improve catalytic cancer therapy. The TENG‐CatSystem is mainly composed of three elements: a human self‐driven triboelectric nanogenerator (TENG) as the electric field stimulator to provide electric pulses with high biosafety, a nanozyme comprising a 1D ferriporphyrin covalent organic framework coated on a carbon nanotube (COF‐CNT) to generate ROS, and a COF‐CNT‐embedded conductive hydrogel that can be injected into the tumor tissues to increase local accumulation of COF‐CNT and decrease the electrical impedances of tissues. Under the human self‐generated electric field provided by the wearable TENG, the peroxidase‐like activity of the COF‐CNT is fourfold higher than that without an electric field. Highly malignant 4T1 breast carcinoma in mice is significantly suppressed using the TENG‐CatSystem. The human self‐driven TENG‐CatSystem not only demonstrates high catalytic ROS generation efficiency for improved cancer therapy, but also offers a new therapeutic mode for self‐driven at‐home therapy.