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The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice

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Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in… Click to show full abstract

Abnormalities in maternal folate and carbohydrate metabolism have both been shown to induce neural tube defects (NTDs) in humans and animal models. Nevertheless, how these two factors might interact in the development of NTDs remains unclear.

Keywords: tube defects; metabolism; interaction maternal; neural tube; development

Journal Title: Developmental Dynamics
Year Published: 2019

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