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Inflammation‐induced white matter injury (WMI) in preterm infants is characterized by microglia activation, astrogliosis, oxidative stress and neurodevelopmental impairments. Microglia and astrocytes activation can be described under a broad spectrum… Click to show full abstract
Inflammation‐induced white matter injury (WMI) in preterm infants is characterized by microglia activation, astrogliosis, oxidative stress and neurodevelopmental impairments. Microglia and astrocytes activation can be described under a broad spectrum of activation profile with extremes described as pro‐inflammatory/neurotoxic (M1 microglia or A1 astrocyte) or anti‐inflammatory/neuroprotective (M2 microglia or A2 astrocyte) in response to stimuli including lipopolysaccharide (LPS) and interleukin 1 (IL‐1). As IL‐1 signalling pathway has been posited as a major driver of inflammation‐induced perinatal WMI, our aim was to evaluate the contribution of IL‐1 modulation in LPS‐induced microglia and astrocyte activation.
Journal Title: International Journal of Developmental Neuroscience
Year Published: 2022
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