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Abstract The discovery of a new spiran based natural product, prenylspirodinone ( 1 ), together with six known cannabinoids ( 2 – 7 ) from the leaves of Cannabis sativa… Click to show full abstract
Abstract The discovery of a new spiran based natural product, prenylspirodinone ( 1 ), together with six known cannabinoids ( 2 – 7 ) from the leaves of Cannabis sativa (Marijuana) is reported. All compounds were screened for antifungal and antibacterial activity against a panel of microbial pathogens and exhibited antimicrobial activities with IC 50 values ranging from 2.6 to 49.6 µM. Compound 2 , a propyl substituted cannabidiol, was determined to be a specific inhibitor against C. albicans (IC 50 11.9 µM) and can be considered as a new lead against Candidiasis.
Journal Title: Tetrahedron Letters
Year Published: 2018
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