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Alarmins released by infarcted myocardium stimulate B cells to differentiate into antibody-producing plasma cells, which then remotely drive the progression of atherosclerosis by producing autoantibodies that accumulate in pre-existing atherosclerotic… Click to show full abstract
Alarmins released by infarcted myocardium stimulate B cells to differentiate into antibody-producing plasma cells, which then remotely drive the progression of atherosclerosis by producing autoantibodies that accumulate in pre-existing atherosclerotic plaques, increasing local inflammation and accelerating the progression towards a vulnerable plaque phenotype.
Keywords:
accelerate atherosclerosis;
alarmins activate;
cells accelerate;
activate cells;
atherosclerosis;
derived alarmins
Journal Title: Nature Reviews Cardiology
Year Published: 2021
Link to full text (if available)
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Journal Title: Nature Reviews Cardiology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!