Photo by sharonmccutcheon from unsplash
Wild‐type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood… Click to show full abstract
Wild‐type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood cells causing sequestration, in addition to antibody‐mediated xenograft injury. One such carbohydrate is N‐glycolylneuraminic acid (Neu5Gc), a sialic acid molecule synthesized in pigs but not in humans. Here, we evaluate livers with and without Neu5Gc in an ex vivo liver xeno perfusion model.
Keywords:
glycolylneuraminic acid;
sequestration;
acid knockout;
vivo;
model;
acid
Journal Title: Xenotransplantation
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Xenotransplantation
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!