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Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

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The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα… Click to show full abstract

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

Keywords: ppar; induced cardiac; low ambient; temperature exposure; ambient temperature; exposure induced

Journal Title: Military Medical Research
Year Published: 2021

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