AKG induces cell apoptosis by inducing reactive oxygen species‐mediated endoplasmic reticulum stress and by suppressing PI3K/AKT/mTOR‐mediated autophagy in renal cell carcinoma
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DOI: 10.1002/tox.23658
Abstract: Background: Alpha‐ketoglutarate (AKG) or 2‐oxoglutarate is a key substance in the tricarboxylic acid cycle (TCA) and has been known to play an important role in cancerogenesis and tumor progression. Renal cell carcinoma (RCC) is the… read more here.
Keywords: cell carcinoma; akg induces; renal cell; akg ... See more keywords
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice
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DOI: 10.1016/j.redox.2021.102088
Abstract: Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different… read more here.
Keywords: alpha ketoglutarate; akg; pressure overload; dysfunction ... See more keywords
Effects of In Ovo Injection of α-Ketoglutaric Acid on Hatchability, Growth, Plasma Metabolites, and Antioxidant Status of Broilers
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DOI: 10.3390/antiox11112102
Abstract: Recently, α-ketoglutaric acid (AKG) has gained importance as an antioxidant. Its dietary supplementation in animals and humans has proved beneficial. Moreover, an extensive group of studies on in ovo feeding has proved that it produces… read more here.
Keywords: day; akg akg; akg; antioxidant status ... See more keywords