Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.071
Abstract: In this study, a "click and hybridization" strategy was developed for the functionalization of polydiacetylene micelles with a targeting aptamer ligand. Decoration of the nanocarriers with an anti-Annexin A2 sequence efficiently triggered enhanced internalization of… read more here.
Keywords: improved targeting; micelles improved; decorated polydiacetylene; aptamer decorated ... See more keywords
AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Nanomedicine"
DOI: 10.2217/nnm-2018-0205
Abstract: AIM The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in the ovarian cancers. METHODS AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap-CIS-NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated and their… read more here.
Keywords: mir inhibited; poly lactic; anti mir; mir ... See more keywords