Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00668
Abstract: N-methylation of nucleic acids, proteins, and peptides is a chemical modification with significant impact on biological regulation. Despite the simplicity of the structural change, N-methylation can influence diverse functions including epigenetics, protein complex formation, and… read more here.
Keywords: methylation; autocatalytic backbone; molecular basis; backbone methylation ... See more keywords
Evidence for Enzymatic Backbone Methylation of the Main Membrane Lipids in the Archaeon Methanomassiliicoccus luminyensis
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DOI: 10.1128/aem.02154-21
Abstract: Butanetriol and pentanetriol dibiphytanyl glycerol tetraethers are membrane lipids recently discovered in anoxic environments. These lipids differ from typical membrane-spanning tetraether lipids because they possess a nonglycerol backbone. ABSTRACT Butanetriol and pentanetriol dibiphytanyl glycerol tetraethers… read more here.
Keywords: methylation; backbone; membrane lipids; backbone methylation ... See more keywords
Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool
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DOI: 10.3390/md19060311
Abstract: Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major… read more here.
Keywords: permeability cyclic; methylation; backbone methylation; methylation useful ... See more keywords