Quorum sensing-based metabolic engineering of the precursor supply in Streptomyces coelicolor to improve heterologous production of neoaureothin.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28400
Abstract: Streptomyces are important industrial bacteria that produce pharmaceutically valuable polyketides. However, mass production on an industrial scale is limited by low productivity, which can be overcome through metabolic engineering and the synthetic biology of the… read more here.
Keywords: metabolic engineering; production; quorum sensing; engineering precursor ... See more keywords
Signature based on metabolic‐related gene pairs can predict overall survival of osteosarcoma patients
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3984
Abstract: Osteosarcoma is a tumour of malignant origin in children and adolescents. Recent progression indicates that it is necessary to develop new therapies to improve the patient's prognosis rather than strengthen anti‐tumour chemotherapy. Researchers recently realised… read more here.
Keywords: related gene; signature based; metabolic related; based metabolic ... See more keywords
Structure Elucidation and Mitigation of Endogenous Interferences in LC-MS-Based Metabolic Profiling of Urine.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04378
Abstract: Liquid chromatography-mass spectrometry (LC-MS) is the main workhorse of metabolomics owing to its high degree of analytical sensitivity and specificity when measuring diverse chemistry in complex biological samples. LC-MS-based metabolic profiling of human urine, a… read more here.
Keywords: endogenous interferences; structure elucidation; chemistry; based metabolic ... See more keywords
Plasma metabolite profiling reveals potential biomarkers of giant cell tumor of bone by using NMR-based metabolic profiles
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DOI: 10.1097/md.0000000000017445
Abstract: Abstract Giant cell tumor (GCT) of bone is a locally aggressive bone tumor, which accounts for 4% to 5% of all primary bone tumors. At present, the early diagnosis and postoperative recurrence monitoring are still… read more here.
Keywords: based metabolic; giant cell; cell tumor; tumor ... See more keywords
BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1005544
Abstract: Recent advances focusing on the metabolic interactions within and between cellular populations have emphasized the importance of microbial communities for human health. Constraint-based modeling, with flux balance analysis in particular, has been established as a… read more here.
Keywords: metabolic modeling; bacarena individual; modeling heterogeneous; based metabolic ... See more keywords
970-P: The Clinical Accuracy Evaluation of Noninvasive Glucometer Based on Metabolic Heat Conformation Method: A Multicenter Study
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-970-p
Abstract: Objective: To evaluate the accuracy of noninvasive glucometer based on metabolic heat conformation (MHC) method by multicenter clinical trial. Methods: This study was a multi-center, open, self-controlled trial. Venous plasma glucose measured by the hexokinase… read more here.
Keywords: method; glucometer based; based metabolic; noninvasive glucometer ... See more keywords
Triple-Negative Breast Cancer Analysis Based on Metabolic Gene Classification and Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2022.902378
Abstract: Triple negative breast cancer (TNBC) has negative expression of ER, PR and HER-2. TNBC shows high histological grade and positive rate of lymph node metastasis, easy recurrence and distant metastasis. Molecular typing based on metabolic… read more here.
Keywords: metabolic subtypes; breast cancer; analysis; based metabolic ... See more keywords
Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson’s Patients, Using In Vivo 31P MRS-Based Metabolic Imaging at 7T
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11030145
Abstract: Abnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor to the progression of neurodegenerative diseases such as Parkinson’s disease (PD). Recent advancements in the field of magnetic resonance (MR) based… read more here.
Keywords: mrs based; 31p mrs; metabolic energetic; based metabolic ... See more keywords
NMR-Based Metabolic Profiling of Edible Olives—Determination of Quality Parameters
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DOI: 10.3390/molecules25153339
Abstract: Edible olive drupes (from Olea europaea L.) are a high-value food commodity with an increasing production trend over the past two decades. In an attempt to prevent fraud issues and ensure quality, the International Olive… read more here.
Keywords: quality; metabolic profiling; based metabolic; profiling edible ... See more keywords