Species-Specific Evolution of Ebola Virus during Replication in Human and Bat Cells
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DOI: 10.1016/j.celrep.2020.108028
Abstract: Summary Ebola virus (EBOV) causes a severe, often fatal disease in humans and nonhuman primates. Within the past decade, EBOV has caused two large and difficult-to-control outbreaks, one of which recently ended in the Democratic… read more here.
Keywords: evolution; ebola virus; bat cells; bat ... See more keywords
Selection of viral variants during persistent infection of insectivorous bat cells with Middle East respiratory syndrome coronavirus
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DOI: 10.1038/s41598-020-64264-1
Abstract: Coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are speculated to have originated in bats. The mechanisms by which these viruses are maintained in individuals or populations of reservoir… read more here.
Keywords: respiratory syndrome; persistently infected; bat cells; bat ... See more keywords
ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells
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DOI: 10.1128/mbio.02566-22
Abstract: Our studies demonstrate that some unexplored sarbecoviruses are capable of replicating in human and bat cells in an ACE2-independent way but need a high trypsin environment. We found that trypsin is not compensated by other… read more here.
Keywords: human bat; trypsin; entry; bat cells ... See more keywords