Bayesian forecasting for intravenous tobramycin dosing in adults with cystic fibrosis using one versus two serum concentrations in a dosing interval.
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DOI: 10.1097/ftd.0000000000000900
Abstract: BACKGROUND Intravenous tobramycin treatment requires therapeutic drug monitoring (TDM) to ensure safety and efficacy when used for prolonged treatment, as in infective exacerbations of cystic fibrosis (CF). The 24-h area under the concentration-time curve (AUC24)… read more here.
Keywords: cystic fibrosis; auc24; tobramycin; intravenous tobramycin ... See more keywords
Towards Precision Dosing of Clozapine in Schizophrenia: External Evaluation of Population Pharmacokinetic Models and Bayesian Forecasting
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DOI: 10.1097/ftd.0000000000000987
Abstract: Supplemental Digital Content is Available in the Text. Background: Therapeutic drug monitoring and treatment optimization of clozapine are recommended, owing to its narrow therapeutic range and pharmacokinetic (PK) variability. This study aims to assess the… read more here.
Keywords: predictive performance; external evaluation; bayesian forecasting; model ... See more keywords
Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients
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DOI: 10.3390/pharmaceutics14091920
Abstract: Voriconazole (VRC) is used as first line antifungal agent against invasive aspergillosis. Model-based approaches might optimize VRC therapy. This study aimed to investigate the predictive performance of pharmacokinetic models of VRC without pharmacogenetic information for… read more here.
Keywords: ill patients; critically ill; without pharmacogenetic; pharmacogenetic information ... See more keywords