Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β‐Tubulin
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DOI: 10.1002/cmdc.201700530
Abstract: Regulation of microtubule assembly by antimitotic agents is a potential therapeutic strategy for the treatment of cancer, parasite infections, and neurodegenerative diseases. One of these agents is nocodazole (NZ), which inhibits microtubule polymerization by binding… read more here.
Keywords: state; water molecules; binding tubulin; protonation ... See more keywords