Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
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DOI: 10.1021/acsinfecdis.6b00172
Abstract: The 20S core particle of the proteasome in Mycobacterium tuberculosis (Mtb) is a promising, yet unconventional, drug target. This multimeric peptidase is not essential, yet degrades proteins that have become damaged and toxic via reactions… read more here.
Keywords: bioactive inhibitors; design selective; rational design; tuberculosis ... See more keywords