CD163+ macrophages infiltration correlates with the immunosuppressive cytokine interleukin 10 expression in tongue leukoplakia
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.228
Abstract: Accumulating evidence suggests that macrophages are involved in the immunoediting of oral squamous cell carcinoma but the role of macrophages in oral carcinogenesis is unclear. We aimed to clarify the role of macrophages in oral… read more here.
Keywords: correlates immunosuppressive; infiltration correlates; macrophages infiltration; immunosuppressive cytokine ... See more keywords
PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004400
Abstract: Background The immune suppressive tumor microenvironment (TME) that inhibits T cell infiltration, survival, and antitumor activity has posed a major challenge for developing effective immunotherapies for solid tumors. Chimeric antigen receptor (CAR)-engineered T cell therapy… read more here.
Keywords: cell activity; cell; cd163 macrophages; car ... See more keywords
CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.154922
Abstract: Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why rupture-prone high-risk plaques do not typically show extensive calcification. Intraplaque hemorrhage (IPH) deposits erythrocyte-derived cholesterol, enlarging the necrotic core and promoting high-risk plaque… read more here.
Keywords: calcification; cd163 macrophages; high risk; risk plaque ... See more keywords
Alternative macrophages in atherosclerosis: not always protective!
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DOI: 10.1172/jci120123
Abstract: Atherosclerosis is a chronic inflammatory disease of the vasculature that is initiated by cholesterol deposition into the arterial wall, which triggers the infiltration of immune and inflammatory cells, including monocytes and macrophages. As atherosclerotic plaques… read more here.
Keywords: always protective; macrophages atherosclerosis; alternative macrophages; atherosclerosis always ... See more keywords