Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens
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DOI: 10.1038/nprot.2016.174
Abstract: Historically, it has been difficult to propagate cells in vitro that are derived directly from human tumors or healthy tissue. However, in vitro preclinical models are essential tools for both the study of basic cancer… read more here.
Keywords: medicine; conditional reprogramming; normal tumor; tissue ... See more keywords
Conditional reprogramming of pediatric airway epithelial cells: A new human model to investigate early‐life respiratory disorders
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.12810
Abstract: Airway epithelial cells (AEC) are quite difficult to access in newborns and infants. It is critically important to develop robust life‐extended models to conduct translational studies in this age group. We propose the use of… read more here.
Keywords: conditional reprogramming; epithelial cells; reprogramming pediatric; airway epithelial ... See more keywords
Abstract A59: Assessment of conditional reprogramming to generate 2D and 3D primary human mammary cell culture models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a59
Abstract: Human mammary gland development and differentiation are tightly regulated by hormones, growth factors, and microenvironmental cues. Rodent models have been used to help gain knowledge about mammary gland biology, but there are significant structural and… read more here.
Keywords: conditional reprogramming; mammary cell; human mammary; culture ... See more keywords