Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
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DOI: 10.1158/2159-8290.cd-18-0385
Abstract: CREBBP, encoding an acetyltransferase, is among the most frequently mutated genes in small cell lung cancer (SCLC), a deadly neuroendocrine tumor type. We report acceleration of SCLC upon Crebbp inactivation in an autochthonous mouse model.… read more here.
Keywords: crebbp; crebbp loss; cancer; cell ... See more keywords