High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
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DOI: 10.1016/j.ejmech.2018.12.051
Abstract: Overexpression of pyruvate dehydrogenase kinases (PDKs) has been widely noticed in a variety of human solid tumors, which could be regarded as an attractive therapeutic target for cancer therapy. In this paper, we present an… read more here.
Keywords: dehydrogenase; dehydrogenase kinases; cancer; cell ... See more keywords
Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis.
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DOI: 10.1182/bloodadvances.2018022392
Abstract: Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) to generate adenosine triphosphate, whereas activated platelets exhibit a high level of aerobic glycolysis, suggesting… read more here.
Keywords: dehydrogenase; aerobic glycolysis; dehydrogenase kinases; thrombosis ... See more keywords