Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1925375
Abstract: Abstract We developed an assay system to evaluate the cytochrome P450 (CYP) 3A4-inhibitory activity of compounds, taking account of their cellular permeability, using intestine-derived cell lines pre-treated with the CYP3A4 inducer 1α,25-dihydroxy-vitamin D3 (250 nM). Ketoconazole… read more here.
Keywords: system; inhibitory activity; cell lines; dihydroxy vitamin ... See more keywords
Opposing effects of 25‐hydroxy‐ and 1α,25‐dihydroxy‐vitamin D3 on pro‐cachectic cytokine‐and cancer conditioned medium‐induced atrophy in C2C12 myotubes
Sign Up to like & getrecommendations! Published in 2019 at "Acta Physiologica"
DOI: 10.1111/apha.13269
Abstract: Loss of skeletal muscle is one of the main features of cancer cachexia. Vitamin D (VD) deficiency is associated with impairment of muscle mass and performance and is highly prevalent in cachectic patients; therefore, VD… read more here.
Keywords: effects hydroxy; muscle; dihydroxy vitamin; hydroxy dihydroxy ... See more keywords
1α, 25-dihydroxy Vitamin D3 containing fractions of Catharanthus roseus leaf aqueous extract inhibit preadipocyte differentiation and induce lipolysis in 3T3-L1 cells
Sign Up to like & getrecommendations! Published in 2019 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-019-2754-7
Abstract: BackgroundTo investigate the potential of Catharanthus roseus leaf aqueous crude extract (CRACE) as a regulator of adipocyte development and function.Methods3T3-L1 adipogenesis model was used to investigate the effect of CRACE on adipogenesis. 3T3-L1 preadipocytes (for… read more here.
Keywords: crace; catharanthus roseus; dihydroxy vitamin; lipolysis ... See more keywords