Hedgehog-interacting protein acts in the habenula to regulate nicotine intake
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209870119
Abstract: Significance Allelic variation in HHIP confers risk of smoking-related lung disease. We show that HHIP is expressed in the medial habenula, where it regulates the motivational properties of nicotine. These findings have relevance for understanding… read more here.
Keywords: habenula regulate; protein acts; interacting protein; acts habenula ... See more keywords
Hedgehog interacting protein as a circulating biomarker in women with obesity: a cross-sectional study and intervention studies.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of medicine"
DOI: 10.1080/07853890.2023.2206162
Abstract: BACKGROUND Although a study found a significant increase in serum hedgehog interacting protein (HHIP) concentrations in impaired fasting blood glucose, impaired glucose tolerance and newly diagnosed T2DM patients, the variation in circulating HHIP levels in… read more here.
Keywords: hedgehog interacting; interacting protein; hhip; obesity ... See more keywords
Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa085
Abstract: Hexavalent chromium [Cr(VI)] is a potent human lung carcinogen. Multiple mechanisms have been proposed that contribute to Cr(VI)-induced lung carcinogenesis including oxidative stress, DNA damage, genomic instability, and epigenetic modulation. However, the molecular mechanisms and… read more here.
Keywords: transformed cells; hedgehog interacting; hhip; hexavalent chromium ... See more keywords