The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109944
Abstract: SUMMARY Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle. Impeding any of those steps induces heterochromatin defects and improper gene expression. The essential histone… read more here.
Keywords: histone chaperone; histone turnover; heterochromatin spreading; fact ... See more keywords
A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303217
Abstract: In chromatin, nucleosomes are composed of ∼146 bp of DNA wrapped around a histone octamer, and are highly dynamic structures subject to remodeling and exchange. Histone turnover has previously been implicated in various processes including… read more here.
Keywords: light inducible; neurospora crassa; chromatin; histone turnover ... See more keywords