Identification of 7,8‐dihydroxy‐3‐phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor
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DOI: 10.1002/jbt.22651
Abstract: We herein report the biological evaluation of 3‐arylcoumarin derivatives (3a‐l) as potential human monoamine oxidase‐A and ‐B (hMAO‐A and hMAO‐B) inhibitors. The result indicated that 7,8‐dihydroxy‐3‐(4‐nitrophenyl)coumarin (3j) was most effective against MAO‐A (inhibition concentration [IC50] = 6.46 ± 0.02 µM)… read more here.
Keywords: hmao enzymes; hmao; identification dihydroxy; monoamine oxidase ... See more keywords