Directed Evolution of Canonical Loops and Their Swapping between Unrelated Serine Proteinase Inhibitors Disprove the Interscaffolding Additivity Model.
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DOI: 10.1016/j.jmb.2018.12.003
Abstract: Reversible serine proteinase inhibitors comprise 18 unrelated families. Each family has a distinct representative structure but contains a surface loop that adopts the same, canonical conformation in the enzyme-inhibitor complex. The Laskowski mechanism universally applies… read more here.
Keywords: proteinase inhibitors; additivity; interscaffolding additivity; loop ... See more keywords