Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
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DOI: 10.1038/s42003-021-02441-2
Abstract: Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a… read more here.
Keywords: administration; intravascular administration; intramuscular intravascular; expression ... See more keywords