A critical point in chiral chromatography–mass spectrometry analysis of ketamine metabolites
Sign Up to like & getrecommendations! Published in 2021 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3112
Abstract: Abstract Ketamine is a widely used dissociative drug, whose quantification in plasma and urine can be of pharmacological, toxicological, and clinical interest. Although tandem mass spectrometry allows the reliable determination of ketamine and its metabolites… read more here.
Keywords: ketamine; chiral chromatography; ketamine metabolites; mass spectrometry ... See more keywords
Enantioselective CE–MS analysis of ketamine metabolites in urine
Sign Up to like & getrecommendations! Published in 2022 at "Electrophoresis"
DOI: 10.1002/elps.202200175
Abstract: The chiral drug ketamine has long‐lasting antidepressant effects with a fast onset and is also suitable to treat patients with therapy‐resistant depression. The metabolite hydroxynorketamine (HNK) plays an important role in the antidepressant mechanism of… read more here.
Keywords: ketamine metabolites; ketamine; enantioselective analysis; chiral selector ... See more keywords