A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1128371
Abstract: Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hamster ovary (CHO)… read more here.
Keywords: biodistribution; replacement; lysosomal replacement; replacement enzymes ... See more keywords