Mistranslation can enhance fitness through purging of deleterious mutations
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DOI: 10.1038/ncomms15410
Abstract: Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic… read more here.
Keywords: deleterious mutations; adaptive evolution; mistranslation; mistranslation enhance ... See more keywords