Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
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DOI: 10.1371/journal.pone.0223892
Abstract: 2'-Deoxyadenosine 5'-monophosphate (dAMP), a deoxyribonucleotide found in DNA, affects intestinal cell growth. The molecular mechanisms underlying gastrointestinal absorption of foreign DNA ingested along with food has hardly been investigated. The aim of this study was… read more here.
Keywords: nucleoside transporter; ecto nucleotidase; nucleotidase cd73; uptake damp ... See more keywords
Transient Down-Regulation of Nucleoside Transporter 3 Gene Expression as a Drug Target in Leishmania major Using Antisense RNA Technology
Sign Up to like & getrecommendations! Published in 2019 at "Iranian Journal of Parasitology"
DOI: 10.18502/ijpa.v14i1.724
Abstract: Background: This study was aimed to silencing the Nucleoside transporter 3 (NT3) permease nucleobases involved in the salvage pathway of Leishmania in order to disrupt purine nucleotide uptake in the parasite and consequently, destruction of… read more here.
Keywords: nucleoside transporter; nt3 gene; gene; leishmania ... See more keywords
Novel variants provide differential stabilisation of human equilibrative nucleoside transporter 1 states
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.970391
Abstract: Human equilibrative nucleoside transporters represent a major pharmaceutical target for cardiac, cancer and viral therapies. Understanding the molecular basis for transport is crucial for the development of improved therapeutics through structure-based drug design. ENTs have… read more here.
Keywords: equilibrative nucleoside; novel variants; human equilibrative; nucleoside transporter ... See more keywords
Inborn Errors of Nucleoside Transporter (NT)-Encoding Genes (SLC28 and SLC29)
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DOI: 10.3390/ijms23158770
Abstract: The proper regulation of nucleotide pools is essential for all types of cellular functions and depends on de novo nucleotide biosynthesis, salvage, and degradation pathways. Despite the apparent essentiality of these processes, a significant number… read more here.
Keywords: transporter encoding; inborn errors; encoding genes; nucleoside transporter ... See more keywords