Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.
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DOI: 10.1021/acs.jmedchem.0c00929
Abstract: KRAS-PDEδ protein-protein interaction represents an appealing target for cancer therapy. However, fast release of high-affinity inhibitors from PDEδ hampered drug binding affinity and antiproliferative activity. To overcome the limitations, the first proteolysis-targeting chimeric (PROTAC) small… read more here.
Keywords: colorectal cancer; pde degraders; pde; kras mutant ... See more keywords