Removal of chromatin by salt-tolerant endonucleases for production of recombinant measles virus.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3342
Abstract: Host cell DNA is a critical impurity in downstream processing of enveloped viruses. Especially, DNA in the form of chromatin is often neglected. Endonuclease treatment is an almost mandatory step in manufacturing of viral vaccines.… read more here.
Keywords: tolerant endonucleases; measles virus; salt tolerant; recombinant measles ... See more keywords
Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice
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DOI: 10.1038/s41541-019-0106-8
Abstract: Following the RTS,S malaria vaccine, which showed only partial protection with short-term memory, there is strong support to develop second-generation malaria vaccines that yield higher efficacy with longer duration. The use of replicating viral vectors… read more here.
Keywords: rmv; long term; recombinant measles; term memory ... See more keywords
A recombinant measles virus vaccine strongly reduces SHIV viremia and virus reservoir establishment in macaques
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DOI: 10.1038/s41541-021-00385-6
Abstract: Replicative vectors derived from live-attenuated measles virus (MV) carrying additional non-measles vaccine antigens have long demonstrated safety and immunogenicity in humans despite pre-existing immunity to measles. Here, we report the vaccination of cynomolgus macaques with… read more here.
Keywords: virus vaccine; viremia; recombinant measles; measles virus ... See more keywords
Antibody effector analysis of prime versus prime-boost immunizations with a recombinant measles-vectored chikungunya virus vaccine.
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DOI: 10.1172/jci.insight.151095
Abstract: Chikungunya is a mosquito-borne disease that causes periodic but explosive epidemics of acute disease throughout the tropical world. Vaccine development against chikungunya virus (CHIKV) has been hampered by the inability to conduct efficacy trials due… read more here.
Keywords: prime boost; boost; antibody; recombinant measles ... See more keywords