The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients
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DOI: 10.1007/s11239-018-1797-9
Abstract: Coagulation Factor XI (FXI) contributes to the pathobiology of sepsis-associated thrombosis and is a target for new therapeutics. Through cleavage of disulfide bonds, FXI becomes reduced (rFXI), accelerating intrinsic coagulation cascade activation. The role of… read more here.
Keywords: sepsis; coagulation; rfxi; septic patients ... See more keywords