Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma
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DOI: 10.3390/ijms24054719
Abstract: Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects… read more here.
Keywords: chit1; macrophage specific; airway remodeling; inhibition macrophage ... See more keywords